December 1, 1998Journal of Hypertension

Angiotensin I-to-II conversion in the human renal vascular bed

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Population

5 subjects with essential hypertension or unilateral renal artery stenosis, not treated with an ACE inhibitor

Design

Other

Authors

ADA.H. Jan DanserVascular Medicine PAPeter J.J. AdmiraalLeiden University Medical Center FDFrans H.M. DerkxMichigan State University

Discussion

Member takes

Implication

Minimal renal angiotensin I-to-II conversion supports compartmentalized intrarenal RAS; leaves open therapeutic targeting independent of systemic levels.

Structured PICO

Population

5 subjects (3 women, 2 men) with essential hypertension (n = 4) or unilateral renal artery stenosis (n = 1), not treated with an ACE inhibitor

Intervention

10-min infusion of 125I-angiotensin I (3.6+/-0.4 x 10(6) cpm/min) directly into the left (n = 4) or right (n = 1) renal artery

Outcome

Angiotensin I extraction and conversion to angiotensin II in the renal vascular bedsurrogate

Less than 10% of arterially delivered angiotensin I is converted to angiotensin II in the human renal vascular bed, indicating highly compartmentalized intrarenal formation of angiotensin II.

Cite This Study

Danser et al. (1998) studied this question.

synapsesocial.com/papers/6a8942c0abe412682d92d428 https://doi.org/10.1097/00004872-199816121-00029

View Full Paper

Ask AI

Bookmark

Implication

Minimal renal angiotensin I-to-II conversion supports compartmentalized intrarenal RAS; leaves open therapeutic targeting independent of systemic levels.

Angiotensin I-to-II conversion in the human renal vascular bed

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin I-to-II conversion in the human renal vascular bed

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider