Key result
In isolated rabbit thoracic aorta, luminal angiotensin I was partially converted to angiotensin II (14% after 60 minutes), a process completely blocked by endothelium removal or ramiprilat.
Population
Isolated rabbit thoracic aorta
Comparison
Angiotensin I (3 x 10 M) applied into the aortic… vs Intact endothelium vs removed endothelium…
Design
Preclinical
Follow-up
60 minutes (incubation)
Authors
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Endothelial ACE may drive vascular angiotensin II generation in models; leaves open translation to human hypertension therapy.
The endothelium is the critical site for angiotensin II production in the vascular wall and the primary target for ACE inhibitors.
Gohlke et al. (1992) studied this question. Angiotensin I and Ramiprilat was evaluated on Conversion of angiotensin I to angiotensin II. In isolated rabbit thoracic aorta, luminal angiotensin I was partially converted to angiotensin II (14% after 60 minutes), a process completely blocked by endothelium removal or ramiprilat.
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