Why the study?
Does captopril prevent angiotensin I to II conversion in isolated perfused porcine coronary and carotid arteries?
Population
Isolated perfused carotid and left anterior descending coronary arteries obtained from 20 pigs.
Comparison
Luminal or adventitial administration of… vs Luminal or adventitial administration of…
Design
Preclinical, The two experiments were performed in random order
Follow-up
40 min
Authors
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Captopril suppresses angiotensin II formation in porcine arteries; confirms ACE mediation at multiple sites but leaves human translation open.
Does captopril prevent angiotensin I to II conversion in isolated perfused porcine coronary and carotid arteries?
This preclinical study demonstrates that vascular angiotensin I to II conversion occurs at both endothelial and extraendothelial sites and is primarily mediated by angiotensin converting enzyme (ACE).
Danser et al. (1995) studied this question.
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