Key result
There is strong evidence for a functionally important renin-angiotensin system in the arterial wall, though its physiological role and the relative importance of local synthesis remain to be elucidated.
This review highlights the evidence for a local vascular renin-angiotensin system and identifies unanswered questions regarding its physiological role.
Supports arterial wall RAS function; leaves open its physiological role and local synthesis importance for further study.
Study of the vascular renin-angiotensin system can be approached in a number of ways. The capacity of the blood vessel to generate angiotensin II, when exposed to angiotensinogen, immunocytochemical demonstration of renin, the presence of renin mRNA and functional changes attributable to local generation of angiotensin have all been used. Although each of these techniques requires careful and critical examination from the standpoint of specificity and sensitivity, there is now strong evidence for a functionally important system in the arterial wall. The relative importance of uptake and local synthesis and the physiological role of this system, as distinct from the renal renin system, still remains to be elucidated.
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Swales et al. (1987) conducted a review in Vascular renin-angiotensin system. There is strong evidence for a functionally important renin-angiotensin system in the arterial wall, though its physiological role and the relative importance of local synthesis remain to be elucidated.
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