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This research investigates the role of CREB and dynorphin in depression-related behaviors in mice.

December 15, 2002Journal of NeuroscienceOpen Access

Inhibition of cAMP Response Element-Binding Protein or Dynorphin in the Nucleus Accumbens Produces an Antidepressant-Like Effect

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This research investigates the role of CREB and dynorphin in depression-related behaviors in mice.
Developed inducible transgenic mice expressing CREB or mutant CREB (mCREB) in forebrain regions.
Used a learned helplessness paradigm to assess behavioral outcomes.
Applied viral-mediated gene transfer to specifically manipulate mCREB expression in the nucleus accumbens.
Blockade of CREB via mCREB overexpression in transgenic mice resulted in an antidepressant-like effect.
Antagonism of dynorphin in the nucleus accumbens produced effects similar to mCREB blockade.
Overexpression of CREB led to an opposite behavioral phenotype, worsening depression symptoms.

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Randomized trial evaluates CREB and dynorphin influence on depression behaviors in mice, suggesting new treatment pathways.

Newton et al. (2002) studied this question.

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