Key result
In patients with cardiovascular disease and preserved ejection fraction, higher arterial velocity pulse index was independently associated with reduced peak oxygen uptake (β = -0.34, P = 0.03).
Why the study?
The relationship between arterial stiffness and exercise tolerance in cardiovascular disease patients with preserved versus reduced ejection fraction was unclear.
Does arterial stiffness correlate with exercise tolerance in CVD patients with preserved versus reduced ejection fraction undergoing cardiac rehabilitation?
Cross-Sectional (n=143)
No
Does arterial stiffness correlate with exercise tolerance in CVD patients with preserved versus reduced ejection fraction undergoing cardiac rehabilitation?
Arterial velocity pulse index (AVI) is independently associated with peak oxygen uptake in CVD patients with preserved ejection fraction, suggesting it may be a useful marker for assessing exercise tolerance in this population.
Arterial velocity pulse index should not yet guide care in preserved EF; leaves open its value as an exercise capacity correlate.
Arterial stiffness contributes to the development of cardiovascular disease (CVD). However, the relationship between the arterial stiffness and exercise tolerance in CVD patients with preserved ejection fraction (pEF) and those with reduced EF (rEF) is unclear. We enrolled 358 patients who participated in cardiac rehabilitation and underwent cardiopulmonary exercise testing at Juntendo University Hospital. After excluding 195 patients who had undergone open heart surgery and 20 patients with mid-range EF, the patients were divided into pEF (n = 99) and rEF (n = 44) groups. Arterial stiffness was assessed using arterial velocity pulse index (AVI) and arterial pressure volume index (API) at rest. The patients in the pEF group were significantly older and had a higher prevalence of coronary artery disease than the rEF group. The pEF group had significantly lower AVI levels and higher API levels than the rEF group. In the pEF group, the peak oxygen uptake (peak VO2) and the anaerobic threshold was significantly higher than those in the rEF group. The peak VO2 was significantly and negatively correlated with AVI and API in the pEF group (All, P < 0.05), but not in the rEF group. Multivariate linear regression analyses demonstrated that AVI was independently associated with peak VO2 (β = −0.34, P < 0.05) in the pEF group. In conclusion, AVI may be a useful factor for assessing exercise tolerance, particularly in CVD patients with pEF.
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Fujiwara et al. (2021) conducted a cross-sectional in Cardiovascular disease (n=143). Arterial velocity pulse index (AVI) vs. Patients with reduced ejection fraction was evaluated on Association between arterial velocity pulse index (AVI) and peak oxygen uptake (peak VO2) in patients with preserved ejection fraction (β = -0.34, p=0.03). In patients with cardiovascular disease and preserved ejection fraction, higher arterial velocity pulse index was independently associated with reduced peak oxygen uptake (β = -0.34, P = 0.03).
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