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October 18, 2023Journal of the American Heart AssociationOpen Access

Arterial Stiffness and Cardiorespiratory Fitness Impairment in the Community

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Why the study?

It was unclear how arterial stiffening might impair cardiorespiratory fitness in community-dwelling individuals.

Is greater arterial stiffness associated with impaired cardiorespiratory fitness in community-dwelling individuals?

Population

2898 Framingham Heart Study participants

Comparison

5 arterial stiffness measures related to multidimensional exercise responses

Design

Cross-sectional observational study

Authors

MNMatthew NayorHeart Failure & TransplantPGPriya GajjarGeneral / Preventive / LipidsPMPatricia E. MillerBoston University

Discussion

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Implication

Arterial stiffness may inform fitness assessment in community adults; leaves open whether stiffness modification improves peak VO2.

Structured PICO

Is greater arterial stiffness associated with impaired cardiorespiratory fitness in community-dwelling individuals?

P
Population
2,898 community-dwelling individuals from the Framingham Heart Study, mean age 54±9 years, 53% women, mean BMI 28.1±5.3 kg/m2
I
Intervention
Arterial stiffness measures (carotid-femoral pulse wave velocity, central pulse pressure, forward wave amplitude, characteristic impedance, augmentation index)
O
Outcome
Peak oxygen uptake (VO2) during maximum effort cardiopulmonary exercise testingsurrogate

Higher arterial stiffness is associated with lower cardiorespiratory fitness and adverse oxygen kinetics in community-dwelling adults, suggesting a potential target for improving fitness.

Cite This Study

Nayor et al. (2023) studied this question.

synapsesocial.com/papers/6a250852c93014b9fc488e95https://doi.org/10.1161/jaha.123.029619
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of age and aerobic capacity on arterial stiffness in healthy adults.1993 · 1,086 citations
  2. 2Cardiorespiratory Fitness as a Quantitative Predictor of All-Cause Mortality and Cardiovascular Events in Healthy Men and Women2009 · 3,073 citations
  3. 3Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction2017 · 1,169 citations
  4. 4Exaggerated Response of Systolic Blood Pressure to Cycle Ergometer2013 · 23 citations
  5. 5Blood Pressure Responses During Exercise: Physiological Correlates and Clinical Implications2022 · 42 citations