Key result
The APOE ε4 allele was associated with an increased risk of dyslipidemia but was not an independent risk factor for cerebral infarction in the Northern Chinese Han population.
Why the study?
The study was conducted to analyze the relationship between the apolipoprotein E gene, including SNPs rs429358 and rs7412, and cerebral infarction in a Northern Chinese Han population.
Is the APOE ε4 allele associated with an increased risk of cerebral infarction and dyslipidemia in a Northern Chinese Han population?
Case-Control (n=873)
No
Is the APOE ε4 allele associated with an increased risk of cerebral infarction and dyslipidemia in a Northern Chinese Han population?
The APOE ε4 allele increases the risk of dyslipidemia but does not independently increase the risk of cerebral infarction in the Northern Chinese Han population.
Answers are grounded in this paper and cite their sources.
APOE ε4 may inform dyslipidemia risk but not cerebral infarction independently; leaves open its broader role pending prospective validation.
BackgroundTo analyze the relationship between apolipoprotein E(APOE) (including the SNPs rs429358 and rs7412) gene and cerebral infarction(CI) in Northern Chinese Han population.Methods457 CI patients and 416 controls (without CI) in Chinese Han population were recruited for our study to test the SNPs by polymerase chain reaction (PCR)-fluorescence probe technique.ResultsThe distribution of APOE genotypes were in Hardy-Weinberg equilibrium, and the frequencies of ɛ4 allele orɛ4 containing were significantdifference between CI and control groups. Compared to ε2 or ε3 carriers, ε4 carriers had a high level of total cholesterol (TC) and low-density lipoprotein cholesterol(LDL-C) and high presenceof dyslipidemia in recruited peoples. And we found APOE ε4 allele was associated with an increased risk of dyslipidemia in the control and CI groups (OR = 2.232, 95% CI= 1.143-4.361, P <0.000; OR = 3.442, 95% CI= 1.885-6.284, P =0.019). However, further logistic regression showed that ɛ4 allele or carriers were not the independent risk factors of CI (OR = 2.232, 95% CI= 1.143-4.361, P =0.144; OR = 3.442, 95% CI= 1.885-6.284, P =0.162).ConclusionAPOE ε4 allele was associated with an increased risk of dyslipidemia (OR = 2.232, 95% CI= 1.143-4.361; OR = 3.442, 95% CI= 1.885-6.284), but ɛ4 allele or carriers were not the independent risk factors of CI in Northern Chinese Han population (OR = 2.232, 95% CI= 1.143-4.361, P =0.144; OR = 3.442, 95% CI= 1.885-6.284, P =0.162).
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Gou et al. (2021) conducted a case-control in Cerebral Infarction (n=873). APOE ε4 allele vs. APOE ε3 allele was evaluated on Risk of cerebral infarction (OR 1.371, 95% CI 0.898-2.049, p=0.144). The APOE ε4 allele was associated with an increased risk of dyslipidemia but was not an independent risk factor for cerebral infarction in the Northern Chinese Han population.
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