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This study aims to evaluate the impact of physiological testosterone replacement on health outcomes in untreated hypogonadal men over 3 years.

Effects of Testosterone Replacement in Hypogonadal Men¹

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This study aims to evaluate the impact of physiological testosterone replacement on health outcomes in untreated hypogonadal men over 3 years.
Conducted a randomized trial with 18 untreated hypogonadal men, treated with transdermal testosterone for 3 years.
Measured bone density, muscle mass, erythropoiesis, prostate volume, energy, sexual function, and lipids over the duration of treatment.
Analyzed changes in serum testosterone levels and various health markers at defined intervals.
Bone mineral density at the lumbar spine increased by 7.7% (P < 0.001) and at the femoral trochanter by 4.0% (P = 0.02) after 24 months.
Mean hematocrit rose from 38.0% to 43.1% within 3 months (P = 0.002).
Prostate volume increased from 12.0 mL to 22.4 mL (P = 0.004) during the first 6 months.

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Randomized trial shows testosterone replacement improves bone density and sexual function in hypogonadal men, suggesting significant health benefits.

Snyder et al. (2000) studied this question.

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Randomized trial shows testosterone replacement improves bone density and sexual function in hypogonadal men, suggesting significant health benefits.