Key result
MicroRNAs dynamically modify cardiovascular disease pathogenesis and offer novel therapeutic and preventive targets.
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The management of cardiovascular risk through lifestyle modification and pharmacotherapy is paramount to the prevention of cardiovascular disease. Epidemiological studies have identified obesity, dyslipidemia, diabetes, and hypertension as interrelated factors that negatively affect cardiovascular health. Recently, genetic and pharmacological evidence in model systems has implicated microRNAs as dynamic modifiers of disease pathogenesis. An expanded understanding of the function of microRNAs in gene regulatory networks associated with cardiovascular risk will enable identification of novel genetic mechanisms of disease and inform the development of innovative therapeutic strategies.
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Quiat et al. (2013) conducted a review in Cardiovascular disease. MicroRNAs was evaluated. MicroRNAs act as dynamic modifiers of cardiovascular disease pathogenesis, presenting potential targets for novel therapeutic strategies and preventive measures.
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