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October 23, 1999BMJ

Preventing the cardiotoxicity of anthracyclines by dexrazoxane

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Key result

Dexrazoxane is highlighted as an advance to prevent anthracycline cardiotoxicity, which becomes uncompensated after a lifetime doxorubicin dose of approximately 450 mg/m2.

Why the study?

Does dexrazoxane prevent cardiotoxicity in children receiving anthracyclines?

Population

Cancer patients, particularly children, receiving anthracyclines (e.g., doxorubicin)

Design

Editorial

Authors

KHK. HellmannAugsburg University

Discussion

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Implication

Dexrazoxane represents an important advance in preventing the cumulative and irreversible cardiotoxicity associated with anthracycline use in cancer treatment, especially in pediatric populations.

Structured PICO

Does dexrazoxane prevent cardiotoxicity in children receiving anthracyclines?

P
Population
Cancer patients, particularly children, receiving anthracyclines (e.g., doxorubicin)
I
Intervention
Dexrazoxane
O
Outcome
Cardiotoxicitysafety

Dexrazoxane represents an important advance in preventing the cumulative and irreversible cardiotoxicity associated with anthracycline use in cancer treatment, especially in pediatric populations.

Cite This Study

K. Hellmann (1999) conducted an editorial in Anthracycline-induced cardiotoxicity. Dexrazoxane was evaluated. Dexrazoxane is highlighted as an advance to prevent anthracycline cardiotoxicity, which becomes uncompensated after a lifetime doxorubicin dose of approximately 450 mg/m2.

synapsesocial.com/papers/6a6a89b1ec7caa0664b37edfhttps://doi.org/10.1136/bmj.319.7217.1085
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chemical, Biological and Clinical Aspects of Dexrazoxane and Other Bisdioxopiperazines1998 · 142 citations
  2. 2Late Cardiac Effects of Doxorubicin Therapy for Acute Lymphoblastic Leukemia in Childhood1991 · 1,427 citations
  3. 3Risk Factors for Doxorubicin-lnduced Congestive Heart Failure1979 · 2,439 citations
  4. 4Prevention of the Cardiotoxic Effects of Adriamycin and Daunomycin in the Isolated Dog Heart1972 · 60 citations
  5. 5Delayed administration of dexrazoxane provides cardioprotection for patients with advanced breast cancer treated with doxorubicin-containing therapy.1997 · 273 citations