What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Familial chylomicronemia syndrome (FCS) (n=166). Intervention: Familial chylomicronemia syndrome (FCS). Primary outcome: Burden of illness and impact on multiple life dimensions.

What question did this study set out to answer?

To assess the impact of familial chylomicronemia syndrome (FCS) on patients' quality of life and daily functioning.

April 26, 2018Journal of clinical lipidologyOpen Access

The burden of familial chylomicronemia syndrome: Results from the global IN-FOCUS study

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Key result

Familial chylomicronemia syndrome imposes a severe clinical and psychosocial burden, with 40% of patients hospitalized in the past year and 94% reporting an impact on employment status.

Population

166 patients with familial chylomicronemia syndrome from 10 countries, median age 33 years, 70% male, 62%…

Design

Cross-sectional

Authors

MDMichael H. DavidsonBoston University MSMichael StevensonUniversity of Southern California AHAndrew HsiehNorthwest African American Museum

Discussion

Member takes

Implication

FCS burden warrants clinical vigilance; leaves open prospective trials of therapies to reduce hospitalizations and employment effects.

Key Points

To assess the impact of familial chylomicronemia syndrome (FCS) on patients' quality of life and daily functioning.
Global web-based survey open to patients with FCS
Questions addressed diagnostic experiences, symptoms, comorbidities, and disease management
Survey conducted with 166 patients across 10 countries
62% of respondents were from the United States, mean age at diagnosis was 9 years
40% experienced hospital admissions in the past year due to FCS complications, with an average of 13 acute pancreatitis episodes over their lifetime
Significant impacts on employment (94%), emotional well-being (58%-66%), and social relationships (68%-82%) were reported.

Study Design

Type

Cross-Sectional (n=166)

Multicenter

Yes

Structured PICO

Population

166 patients with familial chylomicronemia syndrome across 10 countries surveyed to assess the clinical and psychosocial burden of the disease.

Outcome

Patient burden of illness, diagnostic experience, symptoms, comorbidities, disease management, and impact on multiple life dimensionspatient reported

Familial chylomicronemia syndrome imposes a severe clinical and psychosocial burden, characterized by delayed diagnosis, frequent hospitalizations for acute pancreatitis, and significant negative impacts on employment and quality of life.

Cite This Study

Davidson et al. (2018) conducted a cross-sectional in Familial chylomicronemia syndrome (FCS) (n=166). Familial chylomicronemia syndrome (FCS) was evaluated on Burden of illness and impact on multiple life dimensions. Familial chylomicronemia syndrome imposes a severe clinical and psychosocial burden, with 40% of patients hospitalized in the past year and 94% reporting an impact on employment status.

synapsesocial.com/papers/6a6a8ba91e51ef7293b38ef8 https://doi.org/10.1016/j.jacl.2018.04.009

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The burden of familial chylomicronemia syndrome: Results from the global IN-FOCUS study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

The burden of familial chylomicronemia syndrome: Results from the global IN-FOCUS study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider