Key result
Young African American men exhibited significantly greater effective arterial elastance and reduced aortic compliance compared to matched white men, which correlated with differences in left ventricular morphology.
Why the study?
Does ventricular-aortic load differ between young African American and white men, and how does it relate to LV morphology?
Cross-Sectional (n=38)
No
Does ventricular-aortic load differ between young African American and white men, and how does it relate to LV morphology?
Absolute Event Rate: 1.04% vs 0.87%
p-value: p=0.02
Background: We examined several measures of ventricularevascular load as they relate to ECG-derived measures of left ventricular (LV) morphology in a cross-section of 19 young African American and 19 white men.Methods: Measures of steady and pulsatile LV load derived from aortic blood pressure waveforms included: aortic characteristic impedance (Z c ), effective arterial elastance (E a ), arterial compliance, aortic reservoir function, aortic wave reflection (AIx), and total peripheral resistance (TPR).Also derived from the pressure waveform were the rate pressure product (RPP), tensionetime index (TTI), diastolic pressureetime index (DPTI), and the subendocardial viability ratio (SEVR).ECG was used to measure R-wave area, R-wave amplitude, and QRS duration as crude proxies of LV morphology.Results: African American men had greater E a , AIx, TPR and reduced aortic compliance compared with white men (all p < 0.05).There was a positive association between E a , Z c , TPR and LV morphology (p < 0.05).There was an inverse association between arterial compliance and LV morphology (p < 0.05).AIx was not associated with LV morphology.There were no racial differences in aortic reservoir function, RPP, TTI, DPTI, or SEVR.Aortic reservoir function was positively associated with DPTI and SEVR (p < 0.05) and inversely associated with RPP (p < 0.05).Conclusions: In young African American men, LV morphology is influenced by LV load stemming from aortic stiffness and vascular resistance more-so than augmented pressure from wave reflections.Aortic reservoir function is preserved in young African American men, balancing myocardial oxygen supply and demand in the presence of altered vasculareventricular coupling and LV remodeling.
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Heffernan et al. (2009) conducted a cross-sectional in Healthy (normotensive) (n=38). African American race vs. White race was evaluated on Effective arterial elastance (Ea) in mmHg/ml (p=0.02). Young African American men exhibited significantly greater effective arterial elastance and reduced aortic compliance compared to matched white men, which correlated with differences in left ventricular morphology.
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