Key result
Electron tomography of mouse ventricular myocardium revealed that dyadic clefts are remarkably small (average 4.39x10^5 nm^3) and irregularly distributed, which may determine local Ca2+ control.
Population
Mouse ventricular myocardium
Design
Preclinical
Authors
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Structural mapping in mice extends dyadic models; leaves open functional validation and human translation.
The topology of dyadic clefts and neighboring cellular micro-architecture in mouse ventricular myocardium are highly complex and likely major determinants of local Ca2+ control.
Hayashi et al. (2009) studied this question. Electron tomography was evaluated on 3D topologies of dyadic clefts and associated membrane organelles. Electron tomography of mouse ventricular myocardium revealed that dyadic clefts are remarkably small (average 4.39x10^5 nm^3) and irregularly distributed, which may determine local Ca2+ control.
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