June 1, 1993AJP Cell Physiology
Ratio of ryanodine to dihydropyridine receptors in cardiac and skeletal muscle and implications for E-C coupling
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Discussion
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Implication
Receptor ratio differences underscore distinct cardiac E-C coupling; leaves open translation to human mechanisms or therapies.
Key Points
- The study aims to compare ryanodine and dihydropyridine receptor densities in cardiac and skeletal muscle to understand their role in excitation-contraction coupling.
- Measured receptor density in isolated ventricular myocytes from various mammals.
- Analyzed skeletal muscle homogenate and isolated triads.
- Calculated RYR/DHPR ratios across species.
- RYR/DHPR ratios were 0.7 in skeletal muscle homogenate and 0.52 in triads.
- Cardiac myocyte ratios ranged from 3.7 in rabbit to 10.2 in ferret.
- Indicates a significantly higher density of RYR relative to DHPR in cardiac muscles across species.
Cite This Study
Bers et al. (1993) studied this question.