September 21, 2001FEBS LettersOpen Access

Skeletal and cardiac ryanodine receptors bind to the Ca2+‐sensor region of dihydropyridine receptor α1C subunit

Q: What is the clinical evidence from this study?

Study design: Other. Primary outcome: Binding of RyR1 and RyR2 to structural elements of the C-terminal cytoplasmic domain of alpha(1C).

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Key result

Surface plasmon resonance spectroscopy demonstrated that both RyR1 and RyR2 bind to the CB and IQ motifs of the C-terminal cytoplasmic domain of the DHPR alpha(1C) subunit.

Authors

JMJérôme MoutonGamal Abdel Nasser University of Conakry MRMichel RonjatCentre National de la Recherche Scientifique IJIstván JónaUniversity of Debrecen

Discussion

Member takes

Implication

In vitro binding warrants cellular validation; leaves open functional role in excitation-contraction coupling.

PICO

Primary Outcome

Binding of RyR1 and RyR2 to structural elements of the C-terminal cytoplasmic domain of alpha(1C)

Cite This Study

Mouton et al. (2001) studied this question. Surface plasmon resonance spectroscopy demonstrated that both RyR1 and RyR2 bind to the CB and IQ motifs of the C-terminal cytoplasmic domain of the DHPR alpha(1C) subunit.

synapsesocial.com/papers/6a9af4dda5cbe90144f4840c https://doi.org/10.1016/s0014-5793(01)02866-6

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