Population
In vitro translated fragments of skeletal muscle ryanodine receptor, cardiac ryanodine receptor, and…
Comparison
Protein affinity chromatography using DHPR… vs Cardiac ryanodine receptor fragments and cardiac…
Design
Preclinical
Authors
Loading...
Highlights RyR1-specific DHPR interface in skeletal EC coupling; leaves open therapeutic targeting in myopathies.
A specific 37-amino acid sequence in the skeletal muscle ryanodine receptor (RyR1) is critical for its interaction with the dihydropyridine receptor (DHPR) II-III loop, an interaction not shared by the cardiac isoforms.
Leong et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: