May 7, 1999FEBS LettersOpen Access

Conversion of an inactive cardiac dihydropyridine receptor II‐III loop segment into forms that activate skeletal ryanodine receptors

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Population

Skeletal ryanodine receptors and dihydropyridine receptor II-III loop segments

Comparison

Systematic replacement of amino acids of the… vs Wild-type cardiac and skeletal II-III loop…

Design

Preclinical

Authors

XZXinsheng ZhuMinistry of Ecology and Environment GGGeorgina B. GurrolaUniversidad Autónoma del Estado de Morelos MJMing Tao JiangMedical College of Wisconsin

Discussion

Member takes

Implication

May inform isoform-selective RyR modulators; leaves open clinical translation pending mammalian validation.

Structured PICO

Population

Skeletal ryanodine receptors and dihydropyridine receptor II-III loop segments

Intervention

Systematic replacement of amino acids of the cardiac II-III loop (Asp788-Pro814) with their skeletal counterparts

Comparator

Wild-type cardiac and skeletal II-III loop segments

Outcome

Activation of skeletal ryanodine receptorssurrogate

This basic science study identifies specific amino acid residues in the dihydropyridine receptor II-III loop that dictate the differential activation of skeletal versus cardiac ryanodine receptors.

Cite This Study

Zhu et al. (1999) studied this question.

synapsesocial.com/papers/6a9068f93de278877b83fbd4 https://doi.org/10.1016/s0014-5793(99)00496-2

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Conversion of an inactive cardiac dihydropyridine receptor II‐III loop segment into forms that activate skeletal ryanodine receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Conversion of an inactive cardiac dihydropyridine receptor II‐III loop segment into forms that activate skeletal ryanodine receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider