April 23, 1998Biochemistry

Identification of the Minimum Essential Region in the II-III Loop of the Dihydropyridine Receptor α1 Subunit Required for Activation of Skeletal Muscle-Type Excitation−Contraction Coupling

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Population

In vitro model of skeletal muscle sarcoplasmic reticulum

Comparison

Synthesized truncated forms of peptide A vs 20-residue peptide A and further truncated…

Design

Preclinical

Authors

RERoque El-HayekBoston Biomedical Research Institute NINoriaki IkemotoDenso (Japan)

Discussion

Member takes

Implication

Localizes minimal skeletal EC coupling motif; leaves open cardiac translation or therapeutic targeting.

Structured PICO

Population

In vitro model of skeletal muscle sarcoplasmic reticulum

Intervention

Synthesized truncated forms of peptide A (specifically peptide As-10, Arg681-Leu690)

Comparator

20-residue peptide A and further truncated peptides

Outcome

Activation of ryanodine binding and induction of calcium releasesurrogate

The minimum essential unit for triggering skeletal muscle excitation-contraction coupling is localized in the Arg681-Leu690 region of the II-III loop of the dihydropyridine receptor alpha 1 subunit.

Cite This Study

El-Hayek et al. (1998) studied this question.

synapsesocial.com/papers/6a74df1a54045e727a09105d https://doi.org/10.1021/bi972907o

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Identification of the Minimum Essential Region in the II-III Loop of the Dihydropyridine Receptor α1 Subunit Required for Activation of Skeletal Muscle-Type Excitation−Contraction Coupling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of the Minimum Essential Region in the II-III Loop of the Dihydropyridine Receptor α1 Subunit Required for Activation of Skeletal Muscle-Type Excitation−Contraction Coupling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider