May 1, 1997AJP Cell Physiology

A carboxy-terminal peptide of the alpha 1-subunit of the dihydropyridine receptor inhibits Ca(2+)-release channels

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Population

Skeletal and cardiac sarcoplasmic reticulum membranes and skeletal SR Ca-release channels reconstituted into…

Design

Preclinical

Authors

KSK. J. SlavikBaylor College of Medicine JWJinghuang WangHebei University of Chinese Medicine BABahman AghdasiJohns Hopkins University

Discussion

Member takes

Implication

May identify a DHPR C-terminal RyR interaction site; leaves open its role in intact excitation-contraction coupling.

Structured PICO

Population

Skeletal and cardiac sarcoplasmic reticulum (SR) membranes and skeletal SR Ca(2+)-release channels reconstituted into planar lipid bilayers

Intervention

Synthetic peptides corresponding to the carboxy terminus of the alpha 1-subunit of the dihydropyridine receptor (DHPR) (amino acids 1487-1506, multiantigenic peptide, and polypeptide 1381-1627)

Outcome

Inhibition of [3H]ryanodine binding and Ca(2+)-release channel activitysurrogate

A specific sequence in the carboxy terminus of the DHPR alpha 1-subunit may contribute to the functional coupling with the SR Ca(2+)-release channel in muscle excitation-contraction coupling.

Cite This Study

Slavik et al. (1997) studied this question.

synapsesocial.com/papers/6a957f057007bd2ef4e3cbc5 https://doi.org/10.1152/ajpcell.1997.272.5.c1475

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A carboxy-terminal peptide of the alpha 1-subunit of the dihydropyridine receptor inhibits Ca(2+)-release channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A carboxy-terminal peptide of the alpha 1-subunit of the dihydropyridine receptor inhibits Ca(2+)-release channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider