Population
Non-mammalian vertebrate skeletal muscles (e.g., frog, chicken, fish)
Design
Review
Authors
Loading...
CICR via beta-RyR too slow for depolarization-induced release in frogs; leaves open isoform roles in mammalian cardiac Ca2+ handling.
The review highlights that in non-mammalian skeletal muscle, beta-RyR primarily conducts CICR, which is insufficient to explain physiological Ca2+ release during depolarization.
Yasuo Ogawa (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: