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December 1, 2005Biology of Blood and Marrow TransplantationOpen Access

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and Staging Working Group Report

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Authors

AFAlexandra H. FilipovichUniversity of CologneDWDaniel J. WeisdorfBoston UniversitySPSteven Z. PavleticNational Institutes of Health

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Implication

Consensus document standardizes diagnosis and scoring for chronic GVHD, enhancing clinical management.

Key Points

  • The aim is to create standardized criteria for diagnosing chronic graft-versus-host disease (GVHD) and assessing its severity.
  • Developed a clinical scoring system (0-3) for chronic GVHD severity based on organ involvement.
  • Categorized GVHD into acute and chronic types with defined subcategories for diagnosis.
  • Established guidelines for systemic therapy based on severity assessment.
  • Introduced a standardized diagnosis requiring at least one clinical sign or distinctive manifestation.
  • Defined chronic GVHD into classic and overlap syndrome categories for better classification.
  • Recommended systemic treatment for moderate to severe chronic GVHD based on new severity guidelines.

Cite This Study

Filipovich et al. (2005) studied this question.

synapsesocial.com/papers/6a6a9b3fec7caa0664b37fdchttps://doi.org/10.1016/j.bbmt.2005.09.004
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