Key result
Intraoperative hybrid optical neuromonitoring detected increases in CBFi (88.5 ± 125.7%) and decreases in oxCCO (-0.5 ± 0.2 µM) upon initiation of cardiopulmonary bypass.
Why the study?
Adequate maintenance of cerebral blood flow during cardiopulmonary bypass is vital to prevent neurological injury, but current intraoperative neuromonitoring methods are limited.
Can a hybrid optical neuromonitor detect intraoperative changes in cerebral perfusion and metabolism in adults during cardiac surgery with cardiopulmonary bypass?
Comparison
Continuous intraoperative monitoring with a hybrid optical neuromonitor combining B-NIRS and DCS
Design
Clinical translation study
Authors
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Hybrid optical neuromonitor may enable continuous CBF assessment during CPB; leaves open whether it reduces neurological injury.
Observational (n=10)
Can a hybrid optical neuromonitor detect intraoperative changes in cerebral perfusion and metabolism in adults during cardiac surgery with cardiopulmonary bypass?
Hybrid optical neuromonitoring can safely and non-invasively detect real-time changes in cerebral perfusion and metabolism during cardiac surgery, potentially guiding intraoperative management to prevent neurological injury.
Rajaram et al. (2020) conducted an observational in Cardiac surgery with cardiopulmonary bypass (n=10). Hybrid optical neuromonitoring (B-NIRS and DCS) was evaluated on Changes in cerebral blood flow index (CBFi) and oxidation state of cytochrome c oxidase (oxCCO). Intraoperative hybrid optical neuromonitoring detected increases in CBFi (88.5 ± 125.7%) and decreases in oxCCO (-0.5 ± 0.2 µM) upon initiation of cardiopulmonary bypass.
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