Key result
Catheter ablation in manifest WPW syndrome showed a stronger inverse relationship between AT and ARI at 1 week (r=-.64) than 1 day (r=-.46) post-ablation (P<.01).
Why the study?
Does catheter ablation alter activation-recovery intervals and repolarization properties in patients with Wolff-Parkinson-White syndrome?
Population
30 patients with Wolff-Parkinson-White syndrome
Comparison
Catheter ablation vs Baseline measurements before ablation
Design
Cohort
Follow-up
1 week
Authors
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Hypothesis-generating for postablation repolarization in WPW; larger prospective studies needed before clinical adoption.
Observational (n=30)
Does catheter ablation alter activation-recovery intervals and repolarization properties in patients with Wolff-Parkinson-White syndrome?
p-value: p=<.01
Catheter ablation in manifest WPW syndrome leads to a gradual recovery of action-potential duration and repolarization properties over 1 week, reflecting the reversal of electrical remodeling (cardiac memory).
Akahoshi et al. (1997) conducted an observational in Wolff-Parkinson-White syndrome (n=30). Catheter ablation vs. Before ablation was evaluated on Activation-recovery interval (ARI) and relationship between activation time (AT) and ARI (p=<.01). Catheter ablation in manifest WPW syndrome showed a stronger inverse relationship between AT and ARI at 1 week (r=-.64) than 1 day (r=-.46) post-ablation (P<.01).
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