Key result
Among patients receiving long-term warfarin therapy, 81.6% were prescribed at least one potentially interacting drug, including 64.8% prescribed drugs known to increase the INR.
Why the study?
What is the frequency of concurrent use of potentially interacting drugs in patients receiving long-term warfarin therapy?
Population
134,833 patients prescribed long-term warfarin therapy from June 1, 1999 to May 31, 2000, identified from a…
Design
Cohort
Follow-up
1 year (June 1, 1999 to May 31, 2000)
Authors
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High concomitant interacting drug use signals need for closer monitoring; observational data leaves open effects on clinical outcomes.
Cohort (n=134,833)
What is the frequency of concurrent use of potentially interacting drugs in patients receiving long-term warfarin therapy?
A large majority of patients on long-term warfarin are coprescribed medications that can interact to alter INR or increase bleeding risk, highlighting the need for careful medication management.
Wittkowsky et al. (2004) conducted a cohort in Long-term warfarin therapy (n=134,833). Potentially interacting drugs was evaluated on Rates of concomitant use of drugs known to interact with warfarin. Among patients receiving long-term warfarin therapy, 81.6% were prescribed at least one potentially interacting drug, including 64.8% prescribed drugs known to increase the INR.
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