Key result
Head-to-legs g-loads (+Gz) on a short-arm centrifuge decreased femoral artery blood flow by 60% compared to rest, with minimal change (≤10%) in middle cerebral artery blood flow.
Why the study?
The study tested the hypothesis that the hemodynamic reaction to head-to-legs g-loads (+Gz) on a short-arm centrifuge would be analogous to reactions observed in the tilt test or lower body negative pressure test.
Does exposure to head-to-legs g-loads (+Gz) on a short-arm centrifuge alter peripheral arterial blood flow in normal male subjects?
Does exposure to head-to-legs g-loads (+Gz) on a short-arm centrifuge alter peripheral arterial blood flow in normal male subjects?
+Gz centrifugation on a short-arm centrifuge produces orthostatic blood pressure changes in the lower body similar to standing in Earth's gravity, which can be effectively monitored using Doppler flowmetry.
Peripheral arterial blood flow during the exposure to head-to-legs g-loads (+Gz) on a short-arm centrifuge (SAC) has been investigated. The purpose was to use some objective monitoring instruments for testing the hypothesis that the hemodynamic reaction to +Gz would be analogous to the reactions observed in the tilt test and/or the lower body negative pressure (LBNP) test. Six normal male subjects participated in 6 SAC runs with alternating interval g-loads of +1.27 and +2.7 Gz. Blood flow in the femoral (FA) and middle cerebral (MCA) arteries was recorded continuously before, during and after the runs by Doppler flowmetry (CARDIOMED device). It was found that +Gz centrifugation produced typical anti-gravity changes in hemodynamics, i.e., an increase in FA resistance and a decrease in MCR resistance. In comparison to the records at rest, the FA blood flow decreased by 60%; the MCA blood flow changed insignificantly: by no more than –10%. It was confirmed that +Gz centrifugation has the same effects as the Earth’s gravity in standing humans, produces orthostatic blood pressure in the lower part of the body, and initiates the totality of anti-gravity hemodynamic reactions. Doppler recording was a quite useful source of data about the blood flow reaction to +Gz centrifugation.
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Fomina et al. (2023) studied Healthy volunteers (n=6). Head-to-legs g-loads (+Gz) on a short-arm centrifuge vs. Rest was evaluated on Femoral and middle cerebral artery blood flow. Head-to-legs g-loads (+Gz) on a short-arm centrifuge decreased femoral artery blood flow by 60% compared to rest, with minimal change (≤10%) in middle cerebral artery blood flow.
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