What question did this study set out to answer?

To determine if lower vitamin D levels, as indicated by genetic variants, causally influence the risk of multiple sclerosis.

August 25, 2015PLoS MedicineOpen Access

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study

View Full Paper

Ask AI

Bookmark

To determine if lower vitamin D levels, as indicated by genetic variants, causally influence the risk of multiple sclerosis.
Identified SNPs associated with 25-hydroxyvitamin D from a large genome-wide association study (N=33,996).
Examined the effect of these SNPs on 25OHD levels in a cohort of 2,347 participants.
Conducted Mendelian randomization analysis using data from up to 14,498 MS cases and 24,091 controls.
A one-standard-deviation decrease in 25OHD level increases the odds of MS by 2.0 (95% CI: 1.7-2.5; p=7.7×10-12).
Sensitivity analyses showed results persisted with an OR of 1.7 (95% CI: 1.3-2.2; p=2.3×10-5) after controlling for potential biases.
Specific SNPs involved in vitamin D synthesis or metabolism had ORs of 2.1 (p=1×10-9) and 1.9 (p=0.002), respectively.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Mendelian randomization reveals a strong link between genetically lowered vitamin D levels and increased multiple sclerosis risk, suggesting vitamin D's potential role in disease prevention.

Cite This Study

Mokry et al. (2015) studied this question.

synapsesocial.com/papers/6a6abb9d2ef98b0efacb37ed https://doi.org/10.1371/journal.pmed.1001866

View Full Paper

Ask AI

Bookmark

Implication

Mendelian randomization reveals a strong link between genetically lowered vitamin D levels and increased multiple sclerosis risk, suggesting vitamin D's potential role in disease prevention.

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study

Key Points

Discussion

Implication

Cite This Study

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider