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January 1, 2015Circulation Cardiovascular InterventionsOpen Access

Long-Term Results of Transapical Versus Transfemoral TAVI in a Real World Population of 1000 Patients With Severe Symptomatic Aortic Stenosis

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Key result

Transapical TAVI was associated with similar long-term survival compared to transfemoral TAVI in a propensity-matched cohort of patients with severe aortic stenosis (HR 0.89; 95% CI 0.72-1.10; P=0.27).

Why the study?

Does transapical TAVI compared to transfemoral TAVI improve survival and reduce complications in patients with severe symptomatic aortic stenosis?

Population

1000 consecutive patients with severe symptomatic aortic stenosis undergoing TAVI

Comparison

Transapical transcatheter aortic valve… vs Transfemoral transcatheter aortic valve…

Design

Cohort

Follow-up

long term

Authors

GSGerhard SchymikInterventional / Structural CardiologyAWAlexander WürthStädtisches Klinikum KarlsruhePBPeter BramlagePreventive Cardiology

Discussion

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Implication

Transapical access was associated with higher complications after matching; leaves open optimal route selection in contemporary TAVI.

Study Design

Type

Cohort (n=1,000)

Multicenter

No

Structured PICO

Does transapical TAVI compared to transfemoral TAVI improve survival and reduce complications in patients with severe symptomatic aortic stenosis?

P
Population
1000 consecutive patients with severe symptomatic aortic stenosis undergoing transapical or transfemoral TAVI, with 708 analyzed in propensity-matched groups.
E
Exposure
Transapical transcatheter aortic valve implantation
C
Comparator
Transfemoral transcatheter aortic valve implantation
O
Outcome
Access-related complications and long-term survivalhard clinical

Main Result

Hazard Ratio: 0.89 (95% CI 0.72–1.1)

p-value: p=0.27

Transapical and transfemoral TAVI provide comparable long-term survival and 30-day mortality in propensity-matched patients with severe symptomatic aortic stenosis.

Cite This Study

Schymik et al. (2015) conducted a cohort in Severe Symptomatic Aortic Stenosis (n=1,000). Transapical transcatheter aortic valve implantation vs. Transfemoral transcatheter aortic valve implantation was evaluated on Long-term survival (HR 0.89, 95% CI 0.72-1.10, p=0.27). Transapical TAVI was associated with similar long-term survival compared to transfemoral TAVI in a propensity-matched cohort of patients with severe aortic stenosis (HR 0.89; 95% CI 0.72-1.10; P=0.27).

synapsesocial.com/papers/6a6abf2626cff2e2f6f429dchttps://doi.org/10.1161/circinterventions.113.000761

Topics

Transcatheter aortic valve replacementTAVR in low-risk patients
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute and Late Outcomes of Transcatheter Aortic Valve Implantation (TAVI) for the Treatment of Severe Symptomatic Aortic Stenosis in Patients at High‐ and Low‐Surgical Risk2012 · 28 citations
  2. 2Transapical aortic valve implantation - The Leipzig experience.2012 · 20 citations
  3. 3One-Year Outcomes of Cohort 1 in the Edwards SAPIEN Aortic Bioprosthesis European Outcome (SOURCE) Registry2011 · 530 citations
  4. 4The SOURCE Registry: what is the learning curve in trans-apical aortic valve implantation?2010 · 55 citations
  5. 5Risk of acute kidney injury in patients with severe aortic valve stenosis undergoing transcatheter valve replacement2009 · 191 citations