Population
Mice (embryonic and postnatal)
Comparison
Myocardial-specific deletion of the carboxyl… vs Wild-type/control mice
Design
Preclinical
Key result
Myocardial-specific deletion of the carboxyl zinc-finger of Gata6 in mice alters atrioventricular conduction and reduces cell-cycle exit of specified cardiomyocytes toward a conduction system lineage.
Authors
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No immediate clinical implications for conduction disorders; leaves open Gata6's role in human atrioventricular development.
GATA6 is critical for the development and postnatal function of the murine atrioventricular node by promoting cell-cycle exit of specified cardiomyocytes toward a conduction system lineage.
Liu et al. (2015) studied Atrioventricular node development. Myocardial-specific deletion of the carboxyl zinc-finger of Gata6 vs. Control mice was evaluated on Atrioventricular node development and function. Myocardial-specific deletion of the carboxyl zinc-finger of Gata6 in mice alters atrioventricular conduction and reduces cell-cycle exit of specified cardiomyocytes toward a conduction system lineage.