Key result
Direct repression of Isl1 by Nkx2-5 regulates the specification of cardiac progenitors toward different myocardial lineages and ensures proper acquisition of myocyte subtype identity.
Nkx2-5 directly represses Isl1 to control the specification of cardiac progenitors toward ventricular versus nodal myocardial lineages, ensuring proper acquisition of myocyte subtype identity.
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Does not inform clinical practice; hypothesis-generating for Nkx2-5/Isl1 roles in human myocardial lineage specification.
Dorn et al. (2014) studied Cardiogenesis. Nkx2-5 and Isl1 genetic manipulation was evaluated on Cardiomyocyte subtype identity and specification of cardiac progenitors. Direct repression of Isl1 by Nkx2-5 regulates the specification of cardiac progenitors toward different myocardial lineages and ensures proper acquisition of myocyte subtype identity.
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