Key result
Somatostatin produced a dose-dependent decrease in 45Ca uptake in guinea-pig isolated atria, suggesting inhibition of the slow inward Ca current.
Why the study?
Does somatostatin affect 45Ca fluxes in guinea-pig isolated atria?
Does somatostatin affect 45Ca fluxes in guinea-pig isolated atria?
Somatostatin inhibits the slow inward calcium current in guinea-pig atrial fibres, as evidenced by a dose-dependent decrease in calcium uptake.
Somatostatin may inhibit atrial Ca influx in this model; leaves open translation to human electrophysiology or therapy.
The effect of somatostatin (SS, 10(-6) M and 5 X 10(-6) M) was studied on 45Ca fluxes in guinea-pig isolated atria. SS produced a dose-dependent decrease in 45Ca uptake, this effect being dependent on the stimulation rate and Ca concentration in the bathing media. The decrease in 45Ca uptake was more evident at faster (60 and 180 beats min-1) than at slower frequencies (15 beats min-1) and was less evident in high Ca (5.4 mM). SS had no effect on 45Ca efflux. These results suggest that SS inhibits the slow inward Ca current in guinea-pig atrial fibres.
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Díez et al. (1987) studied this question. Somatostatin was evaluated on 45Ca fluxes (uptake and efflux). Somatostatin produced a dose-dependent decrease in 45Ca uptake in guinea-pig isolated atria, suggesting inhibition of the slow inward Ca current.
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