Key result
Prolonged minimal-flow sevoflurane anesthesia (0.5 L/min) for over 8 hours resulted in no significant differences in postoperative hepatic and renal function compared to high-flow anesthesia.
Why the study?
Does prolonged minimal-flow sevoflurane anesthesia affect postoperative hepatic and renal function compared to high-flow anesthesia in female patients undergoing free flap surgery?
RCT (n=40)
Randomized
No
Does prolonged minimal-flow sevoflurane anesthesia affect postoperative hepatic and renal function compared to high-flow anesthesia in female patients undergoing free flap surgery?
Prolonged minimal-flow sevoflurane anesthesia for over 8 hours does not adversely affect postoperative hepatic and renal function compared to high-flow anesthesia.
Answers are grounded in this paper and cite their sources.
May warrant caution with prolonged minimal-flow sevoflurane due to renal impairment; hypothesis-generating and requires larger confirmatory trials.
Background: Minimal-flow and low-flow anesthesia provide many advantages, including reduced costs and pollution, and conservation of body heat and airway humidity. However, low-flow sevoflurane anesthesia is associated with an increase in the circuit concentration of compound A, which causes nephrotoxicity in rats. Therefore, this study was conducted to assess the effects of prolonged minimal-flow sevoflurane anesthesia on hepatic and renal function.
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Choi et al. (2008) conducted an RCT in Patients undergoing free flap surgery (n=40). Minimal-flow sevoflurane anesthesia vs. High-flow sevoflurane anesthesia (5 L/min) was evaluated on Postoperative hepatic and renal function biomarkers (AST, ALT, ALP, total bilirubin, BUN, creatinine) (p=>0.05). Prolonged minimal-flow sevoflurane anesthesia (0.5 L/min) for over 8 hours resulted in no significant differences in postoperative hepatic and renal function compared to high-flow anesthesia.
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