Why the study?
Low-flow sevoflurane is contested among anesthesiologists due to conflicting views on its safety, cost, environmental impact, and concerns regarding Compound A and renal injury.
Does low-flow (< 2 L/min) administration of sevoflurane lead to Compound A production and renal injury compared to higher-flow rates?
Does low-flow (< 2 L/min) administration of sevoflurane lead to Compound A production and renal injury compared to higher-flow rates?
The discussion explores the contested practice of low-flow sevoflurane administration and its associated risks of Compound A exposure and renal injury.
Low-flow sevoflurane renal safety claims remain contested; leaves open need for prospective trials before practice change.
Administration of sevoflurane at low-flow rates is a practice that remains contested amongst anesthesiologists. To some, low-flow rates are advocated as safe, environmentally friendly, and cost-effective. Others remain adherent to the practice of higher-flow rates due to the concerns of Compound A and renal injury. In this episode of the Depth of Anesthesia podcast, we explore the claims that low-flow (< 2 L/min) administration of sevoflurane produces Compound A, and that Compound A exposure leads to renal injury.
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Z. et al. (2022) studied this question.
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