Key result
Patients with inferior-posterior myocardial infarction had significantly higher HBDH and CK-MB enzyme release compared to those with inferior myocardial infarction alone (2P < 0.02 and 2P < 0.05).
Why the study?
Does the magnitude of cardiac enzyme release vary by the specific site of acute inferior myocardial infarction (inferior vs inferior+right ventricular vs inferior-posterior)?
Observational (n=68)
Does the magnitude of cardiac enzyme release vary by the specific site of acute inferior myocardial infarction (inferior vs inferior+right ventricular vs inferior-posterior)?
The magnitude of cardiac enzyme release is significantly higher in inferior-posterior myocardial infarction compared to isolated inferior infarction, reflecting larger vectorcardiographic QRS loop changes.
Vectorcardiographic classification may refine early biochemical profiling in inferior MI; leaves open clinical adoption pending validation.
Sixty eight patients with their first acute inferior myocardial infarction were studied within 24 h of the onset of chest pain by vectorcardiography and biochemical indicators. Patients were divided into three groups according to the vectorcardiographic findings: Group 1 (31 patients with inferior myocardial infarction); Group 2 (26 patients with inferior myocardial infarction and right ventricular involvement); and Group 3 (11 patients with inferior-posterior infarction). Biochemical studies showed that the tendency for the magnitude of enzyme release varied with the site inferior-posterior > inferior+right ventricular > inferior groups. However, the differences between inferior and inferior plus right-ventricular groups were not significant. This suggests that the left ventricle dominates enzyme release regardless, with or without right ventricular involvement in patients with acute inferior myocardial infarction. When the enzyme levels in inferior and inferior-posterior myocardial infarction are compared, the HBDH and CK-MB were significantly higher (2P < 0.02 and 2P < 0.05 respectively). This confirms that when the vectorcardiographic QRS loop changes are large, more enzyme is released during acute myocardial infarction.
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Carson et al. (1994) conducted an observational in first acute inferior myocardial infarction (n=68). Infarct location (inferior-posterior vs inferior+right ventricular vs inferior) vs. Inferior myocardial infarction alone was evaluated on Magnitude of enzyme release (HBDH and CK-MB) (p=2P < 0.02 and 2P < 0.05). Patients with inferior-posterior myocardial infarction had significantly higher HBDH and CK-MB enzyme release compared to those with inferior myocardial infarction alone (2P < 0.02 and 2P < 0.05).
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