Sex, age, and clinical presentation of acute coronary syndromes
Key result
Among patients <65 years with acute coronary syndromes, women were less likely than men to present with ST elevation (OR 0.62; 95% CI 0.53-0.71) and more likely to have unstable angina.
Why the study?
Do sex differences in the clinical presentation of acute coronary syndromes vary by age?
Population
10,253 patients with a discharge diagnosis of acute coronary syndromes from the Euro Heart Survey, including…
Comparison
Female sex (observational comparison) vs Male sex
Design
Cohort
Authors
Discussion
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Member takes
Implication
Age modifies sex differences in ACS presentation; leaves open effects on prognosis and management.
Study Design
Type
Observational (n=10,253)
Multicenter
Yes
Structured PICO
Do sex differences in the clinical presentation of acute coronary syndromes vary by age?
P
Population
10,253 patients with a discharge diagnosis of acute coronary syndromes from the Euro Heart Survey, analyzed to investigate sex and age differences in clinical presentation.
E
Exposure
Female sex (observational comparison)
C
Comparator
Male sex
O
Outcome
Clinical presentation (ST elevation, Q-wave myocardial infarction, unstable angina) and extent of atherosclerosis on angiography
Main Result
Odds Ratio: 0.62 (95% CI 0.53–0.71)
Younger women with acute coronary syndromes are less likely to present with ST elevation and more likely to be diagnosed with unstable angina compared to men of the same age, suggesting a different pathophysiology in younger women.
Cite This Study
Annika Rosengren (2004) conducted an observational in Acute coronary syndromes (n=10,253). Female sex vs. Male sex was evaluated on Presentation with ST elevation in patients <65 years (OR 0.62, 95% CI 0.53-0.71). Among patients <65 years with acute coronary syndromes, women were less likely than men to present with ST elevation (OR 0.62; 95% CI 0.53-0.71) and more likely to have unstable angina.