Key result
In 18-day-old rat fetal cardiomyocytes, nifedipine (3 microM) decreased the Ca2+ current amplitude by 65.9%, revealing a unique DHP-resistant Ca2+ channel isoform (ICa(fe)).
Rat fetal cardiomyocytes possess a unique dihydropyridine-resistant calcium channel isoform that is distinct from typical L-, T-, or N-type channels and diminishes during development.
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Hypothesis-generating for fetal cardiac Ca channel diversity; leaves open relevance to human development or therapy.
Tohse et al. (1992) studied Rat fetal cardiomyocytes. Nifedipine was evaluated on Ca2+ current amplitude. In 18-day-old rat fetal cardiomyocytes, nifedipine (3 microM) decreased the Ca2+ current amplitude by 65.9%, revealing a unique DHP-resistant Ca2+ channel isoform (ICa(fe)).
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