Key result
In vitro autoradiography of rat brains demonstrated distinct regional localization of type I (inhibited by 10 mumol/L Dup753) and type II (inhibited by 10 mumol/L XD329-1) Angiotensin II receptors.
Demonstrates the distinct regional distribution of Angiotensin II type I and type II receptors in the rat brain, providing a basis for understanding the central effects of AII receptor antagonists.
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Subtype mapping of brain AII receptors in vitro needs in vivo confirmation; leaves open distinct clinical roles.
Song et al. (1991) studied this question. Angiotensin II receptor antagonists (Dup753 and XD329-1) was evaluated on Localization of type I and type II Angiotensin II receptors. In vitro autoradiography of rat brains demonstrated distinct regional localization of type I (inhibited by 10 mumol/L Dup753) and type II (inhibited by 10 mumol/L XD329-1) Angiotensin II receptors.
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