In vivo blockade of angiotensin II conversion by captopril enhanced the accumulation of angiotensin I in the brains of hypertensive rats, demonstrating local angiotensin synthesis.
The study provides evidence for an active endogenous renin-angiotensin system in the brain by demonstrating local in vivo synthesis and increased turnover in hypertensive rats.
The missing link in the evidence for an active endogenous renin angiotensin system in the brain has been the demonstration of local angiotensin synthesis in the central nervous system in vivo. In this report the extraction and characterization of angiotensin I and angiotensin II from the brain of rats is described. The accumulation of angiotensin I was enhanced in hypertensive rats when the conversion to angiotensin II was blocked in vivo by the converting enzyme inhibitor captopril.
Ganten et al. (1983) studied Hypertension. Captopril was evaluated on Accumulation of angiotensin I. In vivo blockade of angiotensin II conversion by captopril enhanced the accumulation of angiotensin I in the brains of hypertensive rats, demonstrating local angiotensin synthesis.