July 1, 2021Clinical ScienceOpen Access

Fifty years of research on the brain renin–angiotensin system: what have we learned?

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Population

Transgenic mouse model overexpressing full-length rat angiotensinogen in astrocytes

Comparison

Overexpression of full-length rat… vs Wildtype animals (implied)

Design

Editorial

Authors

ECEdwyn O. Cruz‐LópezErasmus MC EUEstrellita UijlErasmus MC ADA.H. Jan DanserVascular Medicine

Discussion

Member takes

Implication

This commentary highlights that overexpressed angiotensinogen in the brain may be cleaved by an unidentified non-renin enzyme directly into Ang II, bypassing typical metabolism pathways.

Structured PICO

Population

Transgenic mouse model overexpressing full-length rat angiotensinogen in astrocytes

Intervention

Overexpression of full-length rat angiotensinogen in astrocytes

Comparator

Wildtype animals (implied)

Outcome

Brain Ang II levels, sympathetic nervous activity, vasopressin, erythropoiesis, blood pressure, and kidney functionsurrogate

This commentary highlights that overexpressed angiotensinogen in the brain may be cleaved by an unidentified non-renin enzyme directly into Ang II, bypassing typical metabolism pathways.

Cite This Study

Cruz‐López et al. (2021) studied this question.

synapsesocial.com/papers/6a83571c629f3c7ed19bb59a https://doi.org/10.1042/cs20210579

Topics

Hypertension management

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Implication

This commentary highlights that overexpressed angiotensinogen in the brain may be cleaved by an unidentified non-renin enzyme directly into Ang II, bypassing typical metabolism pathways.