This preclinical study demonstrates that the intrinsic brain iso-renin-angiotensin system plays a role in the central regulation of blood pressure in rats.
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Central RAS modulates BP in hypertensive rats; extends preclinical data but leaves open human therapeutic relevance.
Angiotensin is produced by the intrinsic isorenin--angiotensin system. 2. Angiotensin is secreted into the cerebrospinal fluid of nephrectomized rats. 3. Angiotensin in cerebrospinal fluid elevates systemic blood pressure. 4. Rats with hereditary diabetes insipidus are virtually non-responsive to intraventricular angiotensin. 5. Angiotensin II is elevated in the cerebrospinal fluid of spontaneously hypertensive rats. 6. An intraventricular perfusion of the angiotensin II receptor-blocking agent P 113 decreases blood pressure in spontaneously hypertensive rats.
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Ganten et al. (1974) studied this question.
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