What question did this study set out to answer?

The aim is to explore how angiotensin influences blood pressure and hydration through the central nervous system.

January 1, 1982Drug Development Research

The brain renin‐angiotensin system

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Why the study?

Does central administration of converting enzyme inhibitors or angiotensin receptor antagonists reduce elevated blood pressure in rat models of spontaneous hypertension?

Population

Models of spontaneous hypertension in rats

Design

Review

Authors

WSWalter B. SeversPenn State Milton S. Hershey Medical Center JSJoan Y. Summy‐LongPenn State Milton S. Hershey Medical Center LKL. C. KeilCreighton University

Discussion

Member takes

Implication

Central RAS inhibition in rat models does not yet inform human therapy; leaves open its contribution to clinical hypertension.

Key Points

The aim is to explore how angiotensin influences blood pressure and hydration through the central nervous system.
Reviewed literature on the brain renin-angiotensin system and its effects on blood pressure and hydration.
Analyzed the role of angiotensin in circumventricular organs regarding water intake and vasopressin release.
Assessed effects of converting enzyme inhibitors and angiotensin receptor antagonists on hypertension models.
Angiotensin from the central nervous system increases sodium excretion contrary to peripheral effects.
Central administration of inhibitors reduces elevated blood pressure in hypertensive rat models.
The relative activities of central and peripheral renin-angiotensin systems are crucial in blood pressure and hydration regulation.

Structured PICO

Does central administration of converting enzyme inhibitors or angiotensin receptor antagonists reduce elevated blood pressure in rat models of spontaneous hypertension?

Population

Models of spontaneous hypertension in rats

Intervention

Central administration of converting enzyme inhibitors or angiotensin receptor antagonists

Outcome

Blood pressure and hydrationsurrogate

The brain renin-angiotensin system plays a significant role in the central control of blood pressure and hydration, and its inhibition can normalize blood pressure in hypertensive rat models.

Cite This Study

Severs et al. (1982) studied this question.

synapsesocial.com/papers/6a71ee4a35aa2c282ce300ec https://doi.org/10.1002/ddr.430020303

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The brain renin‐angiotensin system

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The brain renin‐angiotensin system

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider