Why the study?
Does central injection of angiotensin II antagonists reduce blood pressure in spontaneously hypertensive and normotensive rats?
Does central injection of angiotensin II antagonists reduce blood pressure in spontaneously hypertensive and normotensive rats?
Central injection of angiotensin II antagonists does not produce a hypotensive effect in spontaneously hypertensive or normotensive rats, suggesting intracranial isoangiotensin plays little role in the pathogenesis of spontaneous hypertension in this model.
No hypotensive effect from central angiotensin II antagonists in rats; leaves open intracranial angiotensin’s role in spontaneous hypertension.
Injections of antagonists of angiotensin II into the cerebral ventricles of normotensive and spontaneously hypertensive rats were performed in order to assess the role of the isorenin-angiotensin system in the brain. 2. No hypotensive effect was obtained in either normotensive or hypertensive rats, suggesting that intracranial isoangiotensin has little role in the pathogenesis of spontaneous hypertension in the rat.
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Elghozi et al. (1976) studied this question.
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