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March 1, 2001Journal of the Renin-Angiotensin-Aldosterone System

Blockade of angiotensin AT1-receptors in the rostral ventrolateral medulla of spontaneously hypertensive rats reduces blood pressure and sympathetic nerve discharge

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Why the study?

Does candesartan cilexetil microinjection into the RVLM reduce blood pressure and sympathetic nerve discharge in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats

Comparison

Bilateral microinjections of the AT1-receptor… vs Similar microinjections in Wistar-Kyoto (WKY) rats

Design

Preclinical

Authors

AAAndrew M. AllenThe University of Melbourne

Discussion

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Implication

Central AT1 blockade may reduce sympathetic drive in hypertensive models; leaves open translation to human RVLM therapies.

Structured PICO

Does candesartan cilexetil microinjection into the RVLM reduce blood pressure and sympathetic nerve discharge in spontaneously hypertensive rats?

P
Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
I
Intervention
Bilateral microinjections of the AT1-receptor antagonist candesartan cilexetil (1 nmol in 100 nl) into the rostral ventrolateral medulla (RVLM)
C
Comparator
Similar microinjections in Wistar-Kyoto (WKY) rats
O
Outcome
Lumbar sympathetic nerve discharge and blood pressure (BP)surrogate

Blockade of AT1-receptors in the RVLM reduces blood pressure and sympathetic nerve discharge in spontaneously hypertensive rats, indicating that Ang II inputs are activated to maintain elevated sympathetic tone in this model.

Cite This Study

Andrew M. Allen (2001) studied this question.

synapsesocial.com/papers/6a70aa10ce524a4339c4618ehttps://doi.org/10.1177/14703203010020012101
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blockade of angiotensin receptors in rat rostral ventrolateral medulla removes excitatory vasomotor tone1996 · 76 citations
  2. 2THE EFFECTS OF CENTRAL ADMINISTRATION OF ANGIOTENSIN II TYPE‐1 RECEPTOR ANTAGONIST, CV‐11974, IN NEPHRECTOMIZED SPONTANEOUSLY HYPERTENSIVE RATS1994 · 14 citations
  3. 3Angiotensin II Type 1 Receptor mRNA Levels in the Brains of Normotensive and Spontaneously Hypertensive Rats1993 · 55 citations
  4. 4Reduced GABA inhibition of sympathetic function in renal-wrapped hypertensive rats1998 · 66 citations
  5. 5Angiotensin Synthesis in the Brain and Increased Turnover in Hypertensive Rats1983 · 323 citations