Key result
Overt albuminuria linked to ~2.5-fold higher odds of sensorimotor peripheral neuropathy.
Cohort
Identification of risk factors for development of diabetic sensorimotor peripheral neuropathy (DSPN) and diabetic autonomic neuropathy (DNA) may help to prevent or modify these complications. The ABCD Trial, a prospective study of diabetic complications, has identified risk factors of the presence and staging of peripheral neuropathy based on neurological symptom scores, neurological disability scores, autonomic function testing and quantitative sensory examination. DSPN is independently associated with diabetes duration [odds ratio (OR) = 1.5 per 10 years], body weight (OR = 1.1 per 5 kg), age (OR = 1.8 per 10 years), retinopathy (OR = 2.3), overt albuminuria (OR = 2.5), height (OR = 1.2 per 10 cm), duration of hypertension (OR = 1.1 per 10 years), insulin use (OR = 1.4), and race/ethnicity [African American vs. non-Hispanic white (OR = 0.4) and Hispanic vs. non-Hispanic white (OR = 0.8)]. DAN is independently associated with diabetes duration (OR = 1.2 per 10 years), body weight (OR = 1.1 per 5 kg), glycosylated hemoglobin (OR = 1.1 per 2.5%), overt albuminuria (OR = 1.6), and retinopathy (OR = 1.8).
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Cohen et al. (1998) conducted a cohort in Non-insulin-dependent diabetes mellitus (NIDDM). Clinical and demographic risk factors (e.g., diabetes duration, body weight, age, retinopathy, albuminuria) was evaluated on Presence and staging of diabetic sensorimotor peripheral neuropathy (DSPN) and diabetic autonomic neuropathy (DAN). Clinical factors including overt albuminuria (OR 2.5), retinopathy (OR 2.3), and diabetes duration (OR 1.5 per 10 years) were independently associated with sensorimotor peripheral neuropathy.
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