SealBio: A novel, non-obturation endodontic treatment based on concept of regeneration

INTRODUCTION: "SealBio", an innovative, non-surgical endodontic treatment protocol, based on "regenerative concept" has been developed to manage pulp and periapically involved teeth. MATERIALS AND METHODS: Subsequent to Institute's ethical clearance, 18 patients presenting with signs and symptoms of pulp and periapical disease were included in the study. (11/M, 7/F; Mean age - 44.7 years; range 15-76 years). The protocol included a modified cleaning and shaping technique involving apical clearing and foramen widening, combined with inducing bleeding and clot formation in the apical region. Calcium-sulphate based cement was condensed with hand pluggers into the canal orifices. An appropriate permanent restoration was given. The patients were followed-up clinically and radiographically at regular interval of 6 months. Six teeth in 3 patients were also evaluated pre and post treatment CBCT at 6-months. RESULTS: The novel treatment protocol was found to be favourable in resolving periapical infection, both clinically and radiographically. CONCLUSIONS: This innovative endodontic treatment protocol highlights and reiterates the importance of cleaning and shaping and puts forth the possible role of stem cells and growth factors in healing after non-surgical endodontic therapy.