Key result
An Estonian ASFV variant with a 14,560 base pair deletion at the 5' end showed reduced virulence, allowing 75% of infected minipigs and 100% of domestic pigs to recover, whereas all wild boar died.
Population
22 pigs (12 minipigs, 5 domestic pigs, and 5 wild boar)
Design
Preclinical
Follow-up
up to 17 days (for wild boar)
Authors
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May guide attenuated ASFV vaccine candidates; leaves open host-specific virulence mechanisms and field validation.
An ASFV variant found in Estonia with a 14560 base pair deletion at the 5' end showed reduced virulence in minipigs and domestic pigs, though it remained lethal to wild boar.
Zani et al. (2018) studied African swine fever (n=22). Estonian ASFV strain was evaluated on Survival rate. An Estonian ASFV variant with a 14,560 base pair deletion at the 5' end showed reduced virulence, allowing 75% of infected minipigs and 100% of domestic pigs to recover, whereas all wild boar died.
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