Key result
The addition of 18F-FDG PET/CT to conventional echocardiography increased the diagnostic sensitivity for infective endocarditis from 39% to 88% in patients with adult congenital heart disease.
Why the study?
Infective endocarditis in adult congenital heart disease is diagnostically challenging due to echocardiographic difficulties, prompting evaluation of 18F-FDG PET/CT in this population.
Does 18F-FDG PET/CT improve the diagnosis of infective endocarditis in patients with adult congenital heart disease?
Cohort (n=22)
No
Does 18F-FDG PET/CT improve the diagnosis of infective endocarditis in patients with adult congenital heart disease?
Absolute Event Rate: 88% vs 39%
18F-FDG PET/CT is being evaluated for its potential to improve the diagnosis of infective endocarditis in patients with adult congenital heart disease, where echocardiography often faces challenges.
18F-FDG PET/CT may aid IE diagnosis in ACHD when echocardiography is limited; leaves open need for prospective validation.
Background:Infective endocarditis (IE) in patients with adult congenital heart disease (ACHD) remains a diagnostic challenge due to difficulties in detecting endocardial lesions by echocardiography. 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) has shown good diagnostic performance in prosthetic valve IE. This study aimed to assess its additional diagnostic value in ACHD-associated IE and to characterize its advantages.
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Ishikita et al. (2021) conducted a cohort in Infective endocarditis in adult congenital heart disease (n=22). 18F-FDG PET/CT vs. Echocardiography alone (modified Duke criteria) was evaluated on Diagnostic sensitivity for definite infective endocarditis. The addition of 18F-FDG PET/CT to conventional echocardiography increased the diagnostic sensitivity for infective endocarditis from 39% to 88% in patients with adult congenital heart disease.
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