Key result
Pre-exercise ingestion of glucose plus fructose increased ischemic reactive hyperemia by 26.35% immediately after anaerobic exercise compared to glucose alone (p < 0.05).
Why the study?
Does the addition of fructose to a pre-exercise glucose supplement improve ischemic reactive hyperemia after anaerobic or aerobic exercise in physically trained men?
RCT (n=20)
Randomized crossover
Does the addition of fructose to a pre-exercise glucose supplement improve ischemic reactive hyperemia after anaerobic or aerobic exercise in physically trained men?
Effect estimate: 26.35% higher
p-value: p=<0.05
The addition of fructose to a pre-exercise glucose supplement increases ischemic reactive hyperemia and nitric oxide bioavailability after anaerobic, but not aerobic, exercise in trained men.
Carbohydrate type before anaerobic exercise may alter vascular reactivity measures; hypothesis-generating and requires prospective confirmation before clinical consideration.
Fernández, JM, Da Silva-Grigoletto, ME, Caballero-Villarraso, J, Gómez-Puerto, JR, Viana-Montaner, BH, Tasset-Cuevas, I, Túnez-Fiñana, I, Pérez-Martínez, P, López-Miranda, J, and Pérez-Jiménez, F. Pre-exercise intake of different carbohydrates modifies ischemic reactive hyperemia after a session of anaerobic, but not after aerobic exercise. J Strength Cond Res 24(6): 1623-1632, 2010-The acute ingestion of a supplement with different glycemic carbohydrates, including fructose, is a typical practice for athletes before exercising. Observational evidence suggests that different metabolic responses may modify the exercise-stimulated endothelium-dependent vasodilation. The purpose of the present study was to investigate whether endothelial reactivity, stimulated by anaerobic exercise (AnE) or aerobic exercise (AE), both performed with glycemic supplementation, is modified by the addition of fructose. Twenty physically trained men ingested an oral dose of glucose (G) or glucose plus fructose (F) 15 minutes before starting a 30-minute session of AnE (10 sets of 10 repetitions of half squat) or AE (cycling). The combination resulted in 4 randomized interventions in a crossover design in which all subjects performed all experimental conditions: G + AnE, F + AnE, G + AE, and F + AE. Ischemic reactive hyperemia (IRH), glycemia, plasma lipoperoxides (LPOs), nitric oxide (NO), and lactate were determined at baseline, exercise, and acute recovery time points. Immediately after AnE, IRH was 26.35% higher in F + AnE than in G + AnE (p < 0.05); this difference rose to 27.24% at the end of the recovery period (p < 0.05). The glycemic peak in F + AnE was lower than in G + AnE (p < 0.05), and there was a second peak during recovery (p < 0.05). There were no differences observed in LPO between anaerobic trials, but the NO bioavailability increased and was higher in F + AnE than in G + AnE after exercise and recovery (p < 0.05). Residual lactate was also higher under the F + AnE condition (p < 0.05). During AE, there were no differences in IRH, glycemia, or NO between groups, but LPO was significantly higher after F supplementation. These results suggest that the addition of fructose to a single G supplement ingested before a glycolitic exercise can modify the glucoregulation and increases ischemic reactive hyperemia.
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Fernández et al. (2010) conducted an RCT in Healthy physically trained men (n=20). Glucose plus fructose vs. Glucose alone was evaluated on Ischemic reactive hyperemia (IRH) immediately after anaerobic exercise (26.35% higher, p=<0.05). Pre-exercise ingestion of glucose plus fructose increased ischemic reactive hyperemia by 26.35% immediately after anaerobic exercise compared to glucose alone (p < 0.05).
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