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October 15, 1993Proceedings of the National Academy of SciencesOpen Access

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.

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Authors

AWAndrew M. WertkinUniversity of PennsylvaniaRTRaymond Scott TurnerCambridge Cognition (United Kingdom)SPSamuel J. PleasureUniversity of California, San Francisco

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Wertkin et al. (1993) studied this question.

synapsesocial.com/papers/6a6aeebb050bc01bbbcb4c46https://doi.org/10.1073/pnas.90.20.9513
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  1. 1Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease1987 · 1,337 citations
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  3. 3Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.1990 · 736 citations