Key result
Over 15 years, poliomyelitis survivors showed declines in CMAP and MUNE, with symptoms of late deterioration associated with residual deficits rather than the magnitude of decline.
Cohort
In polio survivors, summated MUNE is a more sensitive measure of motor unit loss than summated CMAP, and neuron loss follows a proportional rather than linear pattern over time.
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Late symptoms in polio survivors may reflect residual deficits over decline magnitude; leaves open MUNE's role in monitoring pending validation.
Sorenson et al. (2006) conducted a cohort in Poliomyelitis survivors. Time was evaluated on Summated compound muscle action potential amplitudes (CMAP) and summated motor unit number estimates (MUNE). Over 15 years, poliomyelitis survivors showed declines in CMAP and MUNE, with symptoms of late deterioration associated with residual deficits rather than the magnitude of decline.
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